Search results for "PsyArXiv|Neuroscience|Cognitive Neuroscience"
showing 10 items of 8055 documents
The Clock'N Test as a Possible Measure of Emotions: Normative Data Collected on a Non-clinical Population.
2016
International audience; Objective: At present emotional experience and implicit emotion regulation (IER) abilities are mainly assessed though self -reports, which are subjected to several biases. The aim of the present studies was to validate the Clock'N test, a recently developed time estimation task employing emotional priming to assess implicitly emotional reactivity and IER. Methods: In Study 1, the Clock' N test was administered to 150 healthy participants with different age, laterality and gender, in order to ascertain whether these factors affected the test results. In phase 1 participant were asked to judge the duration of seven sounds. In phase 2, before judging the duration of the…
Disentangling the Amyloid Pathways: A Mechanistic Approach to Etiology
2020
Amyloids are fibrillar protein aggregates associated with diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), type II diabetes and Creutzfeldt–Jakob disease. The process of amyloid polymerization involves three pathological protein transformations; from natively folded conformation to the cross-β conformation, from biophysically soluble to insoluble, and from biologically functional to non-functional. While amyloids share a similar cross-β conformation, the biophysical transformation can either take place spontaneously via a homogeneous nucleation mechanism (HON) or catalytically on an exogenous surface via a heterogeneous nucleation mechanism (HEN). Here, we postulate that…
Does predictability matter? Effects of cue predictability on neurocognitive mechanisms underlying prospective memory
2015
Prospective memory (PM) represents the ability to successfully realize intentions when the appropriate moment or cue occurs. In this study, we used event-related potentials (ERPs) to explore the impact of cue predictability on the cognitive and neural mechanisms supporting PM. Participants performed an ongoing task and, simultaneously, had to remember to execute a pre-specified action when they encountered the PM cues. The occurrence of the PM cues was predictable (being signalled by a warning cue) for some participants and was completely unpredictable for others. In the predictable cue condition, the behavioural and ERP correlates of strategic monitoring were observed mainly in the ongoing…
Does daily distress make parents prone to using psychologically controlling parenting?
2016
The aim of the present study was to investigate whether parental daily distress in terms of negative emotions is associated with the daily variation in parental use of psychological control with their children. Whether parental positive emotions play a role in the use of psychological control was also investigated. The participants were 149 Finnish families with a child between the ages of 6 and 7 years. Parents’ negative and positive emotions, children’s misconduct, and parental use of psychological control when interacting with their children were measured daily using diary questionnaires filled in by the mothers and fathers over 7 successive days in the fall term of the children’s first…
Career Adapt-Abilities Scale – Dual Career Form (CAAS-DC): psychometric properties and initial validation in high-school student-athletes
2016
Talented adolescent athletes attempting to sustain academic and vocational training alongside the increasing demands of their athletic career often encounter difficulties, including lower vocational readiness and the challenge of adapting to life after elite sport. Therefore, it is necessary to better understand the specific competencies that youth athletes can draw upon to successfully combine sport and education into a dual career pathway. Building on the existing Career Adapt-Abilities Scale [Savickas & Porfeli, (2012). Career adapt-abilities scale: Construction, reliability, and measurement equivalence across 13 countries. Journal of Vocational Behavior, 80(3), 661–673], we developed a …
Motor imagery in unipolar major depression.
2014
Background: Motor imagery is a potential tool to investigate action representation, as it can provide insights into the processes of action planning and preparation. Recent studies suggest that depressed patients present specific impairment in mental rotation. The present study was designed to investigate the influence of unipolar depression on motor imagery ability. Methods: Fourteen right-handed patients meeting DSM-IV criteria for unipolar depression were compared to 14 matched healthy controls. Imagery ability was accessed by the timing correspondence between executed and imagined movements during a pointing task, involving strong spatiotemporal constraints (speed/accuracy trade-off par…
The reactivity of neonatal rabbits to the mammary pheromone as a probe for viability
2012
International audience; Newborn rabbits depend on a daily nursing interaction with the mother to gain milk and to survive. During this interaction, they localise and seize the nipples displaying a typical behaviour triggered by maternal odour cues. The mammary pheromone constitutes such a signal in domestic rabbits: it elicits sucking-related movements in more than 90% of the pups. However, some newborns remain unresponsive to the presentation of the pheromone, even pups apparently healthy and highly motivated to suck. The main goal of the present study was therefore to explore the link between the unresponsiveness of rabbit pups to the mammary pheromone and their growth and survival in bre…
Inhibition of Rac1 signaling by lovastatin protects against anthracycline-induced cardiac toxicity
2011
Normal tissue damage limits the efficacy of anticancer therapy. For anthracyclines, the clinically most relevant adverse effect is cardiotoxicity. The mechanisms involved are poorly understood and putative cardioprotectants are controversially discussed. Here, we show that the lipid-lowering drug lovastatin protects rat H9c2 cardiomyoblasts from doxorubicin in vitro. Protection by lovastatin is related to inhibition of the Ras-homologous GTPase Rac1. It rests on a reduced formation of DNA double-strand breaks, resulting from the inhibition of topoisomerase II by doxorubicin. Doxorubicin transport and reactive oxygen species are not involved. Protection by lovastatin was confirmed in vivo. I…
Tiam1 as a Signaling Mediator of Nerve Growth Factor-Dependent Neurite Outgrowth
2010
Nerve Growth Factor (NGF)-induced neuronal differentiation requires the activation of members of the Rho family of small GTPases. However, the molecular mechanisms through which NGF regulates cytoskeletal changes and neurite outgrowth are not totally understood. In this work, we identify the Rac1-specific guanine exchange factor (GEF) Tiam1 as a novel mediator of NGF/TrkA-dependent neurite elongation. In particular, we report that knockdown of Tiam1 causes a significant reduction in Rac1 activity and neurite outgrowth induced by NGF. Physical interaction between Tiam1 and active Ras (Ras- GTP), but not tyrosine phosphorylation of Tiam1, plays a central role in Rac1 activation by NGF. In add…
Registered reports for qualitative research.
2022
Researchers are disincentivized from conducting urgently needed qualitative research, argues Veli-Matti Karhulahti. He recommends the adoption of registered reports for qualitative research as a remedial course of action. nonPeerReviewed